Journal article
Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: Implications for cardiorenal syndrome
S Liu, AR Kompa, S Kumfu, F Nishijima, DJ Kelly, H Krum, BH Wang
International Journal of Cardiology | Published : 2013
Abstract
Background To further understand the pathophysiology of concomitant cardiac and renal dysfunction, we investigated molecular, structural and functional changes in heart and kidney that occur when a kidney insult (5/6 nephrectomy-STNx) follows myocardial infarction (MI). Methods Male Sprague Dawley rats (n = 43) were randomized into four groups: Sham-operated MI + Sham-operated STNx (Sham + Sham), MI + Sham-operated STNx (MI + Sham), Sham-operated MI + STNx (Sham + STNx) and MI + STNx. MI/Sham surgery was followed by STNx/Sham surgery 4 weeks later. Cardiac and renal function was assessed prior to STNx/Sham surgery and again 10 weeks later. Hemodynamic parameters were measured prior to sacrif..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We would like to acknowledge Ms Mariana Pacheco, Ms Jemma Court and Ms Alysha Holland for their technical assistance with the animal studies, Mrs Sylwia Glowacka for assistance with Cobas assays and Dr Yuan Zhang for assistance with immunohistochemistry. Shan Liu is a recipient of International Postgraduate Research Scholarship funded by Australian Government and Monash Graduate Scholarship funded by Monash University, Australia. This work was supported by the NHMRC of Australia (program grant no. 546272).